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KMID : 0366919970090010001
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Sungkyun Pharmceutical Journal
1997 Volume.9 No. 1 p.1 ~ p.25
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Pharmacological Studies on the Bioactive Constituents from the Leaves of Platycarya strobilacea
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Cho Tai-Soon
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Abstract
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In an effort to screen new antitumor agents from various extraction-fractions of 60 plants cytotoxicity-oriented screening was performed. Based on the high cytotoxicity against the human cell lines Platycarya strobilacea was selected and 9 main components were isolated from its leaves for further investigation of in vitro cytotoxicity and in vivo antitumor activity as well as their other putative biological activities such as antiinflammatory, antiallergic, and whitening effects.
Seven human tumor cell lines were employed for the observation of in vitro cytotoxicity and P388-leukemia were used for the evalution of in vivo antitumor effects.
Compound 1 showed the highest cytotoxicity against all human tumor cell lines tested. In experiment of in vivo antitumor activity, compound 1 increased the life-span of CDF1 mice treated with an ascitic form of P388 leukemia.
In experiments to observe antiinflammatory and antiallergic activity, compound 1 reduced the IL-3-and IL-5-dependent Y16 cell growth, while they did not change cyclooxygenase activity of prostaglandin H_2 synthase. Compound 1 and 2 strongly inhibited the specific binding of PAF to its receptors in rabbit platelet rich plasma.
Compound 3, 6, 8, and 9 showed tyrosinase activity.
Taken together the results demonstrated that compound 1 has the potent cytotoxicity against the various cancer cell lines, while other compounds exhibit the moderate antitumor, antiinflammatory, antiallergic, and whitening effects.
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